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Actualités

• Making 1H–1H Couplings More Accessible and Accurate with Selective 2DJ NMR Experiments Aided by 13C Satellites
• A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein
• Alexis Verger takes part in the Radio France programme "la Science CQFD" on the subject of artificial intelligence.
• Clément Danis received funding from France Alzheimer association
• Assessment of machine-learning predictions for the Mediator complex subunit MED25 ACID domain interactions with transactivation domains
• Launch of the European Doctoral Network TAME (TAu-ImMunE)
• Magnetic resonance investigation of conformational responses of tau protein to specific phosphorylation
• Lab members are teaching in the new International Master in Sustainable Drug Discovery (S-DISCO)
• Conformation and Affinity Modulations by Multiple Phosphorylation Occurring in the BIN1 SH3 Domain Binding Site of the Tau Protein Proline-Rich Region
• We joined EuroTau2023 and the Rainwater prize ceremony with 4 posters to present the team research projects on Tau protein
• Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses
• The structure of pathogenic huntingtin exon 1 defines the bases of its aggregation propensity
• Danai Moschidi received her PhD degree
• Inauguration of the 1.2 GHz NMR spectrometer in Lille
• 2022 Christmas lunch & golf initiation
• Congrats to Davy Sinnaeve for his Habilitation (HDR)!
• The lab is partner of 3 new projects in the ANR AAPG2022 call: NanoTarget, Coronem & Haptoheme
• Deciphering the Structure and Formation of Amyloids in Neurodegenerative Diseases With Chemical Biology Tools
• Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
• 2021 Group Christmas photo
• IPL Research Highlight: The S100B protein protects the brain from toxic protein Tau aggregates
• X. Hanoulle presented his latest results to the 2nd INTEGRATIVE STRUCTURAL BIOLOGY meeting
• CNRS News: First NMR analysis of the Main Protease of SARS-CoV-2
• Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
• I. Landrieu presented her latest results to the EUROTAU meetings
• NMR Spectroscopy of the Main Protease of SARS-CoV-2 and Fragment-Based Screening Identify Three Protein Hotspots and an Antiviral Fragment
• Phosphorylation and O-GlcNAcylation of the PHF-1 Epitope of Tau Protein Induce Local Conformational Changes of the C-Terminus and Modulate Tau Self-Assembly Into Fibrillar Aggregates
• Take your PIC
• Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer’s disease
• Davy Sinnaeve obtained a young researchers ANR funding. Ultrahigh resolution and anisotropic NMR to unravel conformational ensembles of flexible biopolymers: A general strategy – URANUS
• Probing Long-Range Anisotropic Interactions: a General and Sign-Sensitive Strategy to Measure 1H- 1H Residual Dipolar Couplings as a Key Advance for Organic Structure Determination