We are pleased to announce the launch of the European Doctoral Network TAME (Tau-Immune), which we will coordinate as CNRS beneficiary for the next 4 years.
Visit our website https://tame-itn.eu/ and join us: we are recruiting 9 talented doctoral candidates for positions all over Europe.
- Eligible candidates have to be in the first four years of their research careers and in possession of a European Master’s degree or equivalent but not yet awarded with a doctoral degree
- The researchers must not have resided or carried out their main activity (work, studies, etc.) in the hosting country for more than 12 months in the 3 years immediately prior to the start of the contract date.
- We are committed to equal opportunity recruitments.
- The complete application must be received before 31 January 2024 (application deadline);
- The applicant must possess a European Master’s degree or equivalent at the application deadline;
- The candidate must have an excellent proficiency of English (based on the TOEFL test).
- Merit and excellence criteria (25%): academic track record will be one of the considered criteria (examination and dissertation marks, courses followed, internships, etc.);
- Knowledge and experience in the field (20%);
- Non-academic skills, such as communication and teamwork skills (20%);
- Fluency in English and criteria such as previous mobility, teaching experience, publications, awards (25%);
- external expert assessments (reference letter(s)) (10%).
| From January 2024 | https://tame-itn.eu/
The programme is organized by 4 European universities, i.e. Ghent University, Medical University of Gdańsk, University of Lille and the University of Groningen.
Students will perform a master thesis in one of the partner institutions or with one of the numerous associated partners (incl. industry, competent authorities and research institutions).
EMR 9002 lab members are giving lectures in the third semester of this 2-year Master programme. Specifically, we are involved in both the Block of teaching units 2: Sustainable approaches to identify hits and in the Block of teaching units 4: Sustainable approaches to validate target engagement.
Several stages in the drug discovery process are discussed, i.e. NMR fragment screening, NMR spectroscopy of proteins, recombinant expression of protein targets, biomolecular interaction techniques (NMR, SPR, PROTAC, ITC…), Structural biology (NMR, crystallography, Cryo-EM…).
Congratulations to Danai Moschidi who received her PhD degree on January 25th 2023.
After 3 years, Danai Moschidi presented her thesis entitled « Structural and Functional study of the HEV ORF3 protein by solution NMR » to the jury (Dr. Anja Böckmann, Dr. Jérôme Gouttenoire, Dr. Laurence Cocquerel and Dr. Xavier Hanoulle) and she received her PhD degree from the University of Lille.
Danai Moschidi was supported by a PhD fellowship from the ANRS.
Dr. Davy Sinnaeve obtained his Habilitation (French HDR) on October 11th 2022.
Following both a high-level presentation and discussion the committee (Fabien Ferrage, Patrick Giraudeau, Carine Van Heijenoort, Burkhard Luy and Isabelle Landrieu) awarded him its Habilitation and expressed his warm congratulations.
The lab is a partner of 3 new AAPG2022 ANR projects
NanoTarget – Intracellular targeting of Tau-specific single domain antibodies
Partner: Isabelle Landrieu – Coordinator: Christian Hackenberger (DE) – PRCI ANR/DFG
Coronem – Characterization of the role of betacoronavirus M protein in viral assembly
Partner: Xavier Hanoulle – Coordinator: Sandrine Belouzard – PRC ANR
Haptoheme – Molecular mechanisms of heme acquisition by Haemophilus influenzae Hgps
Partner: Vincent Villeret – Coordinator: Nathalie Dautin – PRC ANR
⏐ From October, 2022 ⏐ aapg-2022-selection-PRCI-DFG.pdf aapg-selection-2022-4-28072022.pdf
X. Hanoulle at the 2nd INTEGRATIVE STRUCTURAL BIOLOGY meeting: “NMR of SARS-COV-2 main protease (3CLpro) for drug development”.
⏐ Date: November 29-December 3, 2021 ⏐ https://bsi-2021.cnrs.fr
Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer’s disease
The scientific strategy of the multidisciplinary scientific programme of DISTALZ is organised from bench to society along four major axes where the wide and complementary expertise of DISTALZ partners gives rise to multi-directional approaches allowing filling up the main gaps in our understanding of the Alzheimer’s disease pathology. In the field of education and training, DISTALZ has initiated several programs devoted specifically to scientific and clinical training in the field of genomic, neurobiology, medicine, psychology and ethics. Some of these programs were created de novo to present a new original training and academic offer that was not available before. Such achievement was possible thanks to the momentum created around DISTALZ scientific expertise and original assemble. This program has been developed along five major educational axes.
The development of an AD-specific academic program in existing regional masters and the contact with other European universities maintained.
An international summer school targeting physicians and scientists with a major interest in AD and neurological disorders, has been implemented as part of an educational program covering both theoretical and practical aspects. This educational program will be renewed every two years.
In the field of social and healthcare sciences, thematic workshops have been organized around the theme of anticipation of dementia diagnosis. Each year, a DISTALZ research day is organized during the National Summer University on Ethics in AD and neurodegenerative diseases. It was attended in 2014 by more than 200 participants from various background.
A specific training course that could help to harmonize best practice in medical, paramedical and social care, to network professionals centers and memory consultations and to improve participation in cohorts and clinical studies is in progress.
LabEx ⏐ 2012-2024 ⏐ https://anr.fr/en/funded-projects-and-impact/funded-projects/project/funded/invest/b70d8a08a7fad5b3bd3dc38ea7245e83/?tx_anrprojects_funded%5Bcontroller%5D=Funded&cHash=a871c3fe6b6bcaf28aced999eb76c7ba ⏐ http://distalz.univ-lille2.fr/project/
Ultrahigh resolution and anisotropic NMR to unravel conformational ensembles of flexible biopolymers: A general strategy
Understanding the function of flexible biopolymers such as disordered proteins, glycans or oligonucleotides requires insight in their conformational ensembles. Liquid-state NMR is the leading technique reporting on this. Unfortunately, fast structural averaging on the NMR time scale strongly reduces chemical shift dispersion, which, given the many 1H-1H couplings, results in spectral overlap. This obstructs resolving 1H NMR data, such as residual dipolar couplings (RDCs), that report on long-range structural order and allosteric changes. In addition, molecular flexibility has until now greatly complicated the interpretation of RDC data. URANUS proposes a general strategy to solve both these issues for any biopolymer. First, it capitalizes on recent ‘pure shift’ methods to boost spectral resolution and RDC extraction by an order of magnitude. Second, a recently introduced method is used to treat RDC data in presence of molecular flexibility: Molecular Dynamics simulations with Orientational Constraints (MDOC). Both these approaches have recently been introduced for small molecule NMR, and in this project their use will be explored for the first time for conformational ensemble analysis of biopolymers. This approach will be directly applied to two biomedically relevant case-studies where insight in the conformational ensemble is key to comprehend the relation between molecular structure and biological activity. (1) The proline-rich region of the non-structural protein 5A (NS5A), a disordered protein region where it has been shown that transient conformations that are yet unidentified play an essential role in Hepatitis C virus RNA replication. (2) Oligosaccharides fragments of the structurally heterogeneous and flexible polysaccharide heparin, which is a clinically very important anticoagulant whose activity is determined by specific sulfation patterns, but conformational ensemble as a function of these patterns is not yet fully understood.
URANUS aims to take the determination of conformational ensembles to a next level by maximizing the amount of spectral information and facilitating their translation into the ensemble. The goal is to provide a better description of conformational ensembles than currently feasible, allowing to resolve the subtleties necessary to clearly link biopolymers molecular structure to biological activity. On the mid-term, we will create a widely accessible toolbox of techniques that is generally applicable to any biopolymer.
⏐ From January, 2021 ⏐ https://anr.fr/Project-ANR-20-CE29-0015