Complementary studies by Zhao et al.¹ and Chen et al.² reveal how an intrinsically disordered region in MED13 controls mutually exclusive binding of RNA Polymerase II and CDK8 kinase module to Mediator, switching Mediator and transcription activation on and off.

| Published August 22, 2024 | DOI: 10.1016/j.molcel.2024.07.027